Nonoperative Management of Locally Advanced Resectable Cutaneous Squamous Cell Cancer of the Head and Neck with PD-1 Blockade.

Busam, Klaus; Scholfield, Daniel; Ganly, Ian; Ow, Thomas J; Riaz, Nadeem; Patel, Snehal G; Morris, Luc G T; Boe, Lillian A; Finnegan, Emma; Pulitzer, Melissa; Wong, Richard J; Kavanagh, Fergal G; Instrum, Ryan S; Eagan, Alana J; Wong, Winston; Barker, Christopher A; Fetten, James

doi:10.1158/1078-0432.CCR-26-0123

Nonoperative Management of Locally Advanced Resectable Cutaneous Squamous Cell Cancer of the Head and Neck with PD-1 Blockade.

2026-05-29, Clinical Cancer Research (10.1158/1078-0432.CCR-26-0123) (online)
Klaus Busam, Daniel Scholfield, Ian Ganly, Thomas J Ow, Nadeem Riaz, Snehal G Patel, Luc G T Morris, Lillian A Boe, Emma Finnegan, Melissa Pulitzer, Richard J Wong, Fergal G Kavanagh, Ryan S Instrum, Alana J Eagan, Winston Wong, Christopher A Barker, and James Fetten (?)

Neoadjuvant PD-1 blockade has shown marked efficacy before surgery in patients with head and neck cutaneous squamous cell cancer (CSCC). However, the potential for PD-1 blockade as a definitive, non-operative therapy remains uncertain.

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Nonoperative Management of Locally Advanced Resectable Cutaneous Squamous Cell Cancer of the Head and Neck with PD-1 Blockade.