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Using population-wide electronic health records for timely contemporary assessment of cardiovascular disease risk prediction model performance: COVID-19 impact on the SCORE2 models.

2026-03-29, European journal of preventive cardiology (10.1093/eurjpc/zwag179) (online)
Angela Wood, Spiros Denaxas, Kamlesh Khunti, Naveed Sattar, L Pennells, Emanuele di Angelantonio, S H Wild, Spencer J Keene, Elena Raffetti, Carmen Petitjean, Thomas Bolton, Alexia Sampri, Genevieve Cezard, Samantha Ip, Fionna Chalmers, Anna J Stevenson, Stelios Boulitsakis Logothetis, Lois G Kim, and Stephen Kaptoge (?)
Risk estimation is key for primary prevention of cardiovascular diseases (CVD). The European Society of Cardiology recommends SCORE2, SCORE2-OP (Older Persons), and SCORE2-Diabetes (collectively, the SCORE2 family-of-models (FOMs)) for 10-year CVD-risk estimation. As the COVID-19 pandemic was associated with higher CVD incidences, we externally validated the SCORE2-FOMs using contemporary nationwide data and assessed the need for adaptation.
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